Scientific Pickshttp://www.scienceandtechnology.de/index.htmlHot News!engilbert.schoenfelder@scienceandtechnology.deCopyright 2008 schoenfe2009-10-21T12:41:01+02:00 hourly 1 2000-01-01T12:00+00:00 Mon, 25 Aug 2008 01:54:10 +0200Prenatal Bisphenol A Exposure and Early Childhood Behaviorgilbert.schoenfelder@scienceandtechnology.deBisphenol AhumanExposure2009-10-21T12:41:01+02:00http://www.scienceandtechnology.de/page18/page6/files/http:/www.ehponline.org/docs/2009/0900979/abstract.html#unique-entry-id-68http://www.scienceandtechnology.de/page18/page6/files/http:/www.ehponline.org/docs/2009/0900979/abstract.html#unique-entry-id-68Oct4-Induced Pluripotency in Adult Neural Stem Cellsgilbert.schoenfelder@scienceandtechnology.deHome2009-02-07T00:25:14+01:00http://www.scienceandtechnology.de/page18/page6/files/09ea66fd8f739f29208e83b726531e82-67.html#unique-entry-id-67http://www.scienceandtechnology.de/page18/page6/files/09ea66fd8f739f29208e83b726531e82-67.html#unique-entry-id-67Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factorsgilbert.schoenfelder@scienceandtechnology.deAngiogenesis2008-12-12T00:15:42+01:00http://www.scienceandtechnology.de/page18/page6/files/050e7c3fd192b3d39fa46403e0904c22-66.html#unique-entry-id-66http://www.scienceandtechnology.de/page18/page6/files/050e7c3fd192b3d39fa46403e0904c22-66.html#unique-entry-id-66A new type of ERK1/2 autophosphorylation causes cardiac hypertrophygilbert.schoenfelder@scienceandtechnology.deErk2008-12-09T01:10:11+01:00http://www.scienceandtechnology.de/page18/page6/files/c54f960a7852098d3efd22138ea85ca4-65.html#unique-entry-id-65http://www.scienceandtechnology.de/page18/page6/files/c54f960a7852098d3efd22138ea85ca4-65.html#unique-entry-id-65Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters gilbert.schoenfelder@scienceandtechnology.deTranscription2008-12-05T11:57:14+01:00http://www.scienceandtechnology.de/page18/page6/files/6d74fdee349b85178797461cba836de9-63.html#unique-entry-id-63http://www.scienceandtechnology.de/page18/page6/files/6d74fdee349b85178797461cba836de9-63.html#unique-entry-id-63RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters gilbert.schoenfelder@scienceandtechnology.deTranscription2008-12-05T11:45:34+01:00http://www.scienceandtechnology.de/page18/page6/files/031a1c049cd7f7c04461ce157a0219b9-62.html#unique-entry-id-62http://www.scienceandtechnology.de/page18/page6/files/031a1c049cd7f7c04461ce157a0219b9-62.html#unique-entry-id-62Divergent Transcription from Active Promoters gilbert.schoenfelder@scienceandtechnology.deTranscription2008-12-05T11:42:30+01:00http://www.scienceandtechnology.de/page18/page6/files/5e559200279a33c27eaaae93ce111f05-61.html#unique-entry-id-61http://www.scienceandtechnology.de/page18/page6/files/5e559200279a33c27eaaae93ce111f05-61.html#unique-entry-id-61A role for VEGF as a negative regulator of pericyte function and vessel maturationgilbert.schoenfelder@scienceandtechnology.devegf2008-12-05T01:19:41+01:00http://www.scienceandtechnology.de/page18/page6/files/ac8c95c3e83fae42fcfc0467dcb3cf84-60.html#unique-entry-id-60http://www.scienceandtechnology.de/page18/page6/files/ac8c95c3e83fae42fcfc0467dcb3cf84-60.html#unique-entry-id-60Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiologygilbert.schoenfelder@scienceandtechnology.deHome2008-12-05T01:17:07+01:00http://www.scienceandtechnology.de/page18/page6/files/1bb9670c7c6aa3c60cccfb4447fae372-59.html#unique-entry-id-59http://www.scienceandtechnology.de/page18/page6/files/1bb9670c7c6aa3c60cccfb4447fae372-59.html#unique-entry-id-59The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophilagilbert.schoenfelder@scienceandtechnology.deDevelopment2008-12-05T01:11:24+01:00http://www.scienceandtechnology.de/page18/page6/files/4bec163d356aeb8406e4a0f5c25f2108-58.html#unique-entry-id-58http://www.scienceandtechnology.de/page18/page6/files/4bec163d356aeb8406e4a0f5c25f2108-58.html#unique-entry-id-58Cell biology: Nuclear order out of chaosgilbert.schoenfelder@scienceandtechnology.deHome2008-12-05T01:08:04+01:00http://www.scienceandtechnology.de/page18/page6/files/b0fbd80d310a6a4dcee365ba26e616af-57.html#unique-entry-id-57http://www.scienceandtechnology.de/page18/page6/files/b0fbd80d310a6a4dcee365ba26e616af-57.html#unique-entry-id-57Alternative isoform regulation in human tissue transcriptomesgilbert.schoenfelder@scienceandtechnology.deOhne2008-11-27T01:05:04+01:00http://www.scienceandtechnology.de/page18/page6/files/f8059837d9cd9f830f18bb8ecf88205c-56.html#unique-entry-id-56http://www.scienceandtechnology.de/page18/page6/files/f8059837d9cd9f830f18bb8ecf88205c-56.html#unique-entry-id-56Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifengilbert.schoenfelder@scienceandtechnology.deEstrogen2008-12-05T01:01:03+01:00http://www.scienceandtechnology.de/page18/page6/files/fb8221c75bcd538182cf8ec428fe0349-55.html#unique-entry-id-55http://www.scienceandtechnology.de/page18/page6/files/fb8221c75bcd538182cf8ec428fe0349-55.html#unique-entry-id-55Sox18 induces development of the lymphatic vasculature in micegilbert.schoenfelder@scienceandtechnology.deAngiogenesis2008-12-05T00:58:39+01:00http://www.scienceandtechnology.de/page18/page6/files/b3477a2f10ff1f726c662d21c87ef2d4-54.html#unique-entry-id-54http://www.scienceandtechnology.de/page18/page6/files/b3477a2f10ff1f726c662d21c87ef2d4-54.html#unique-entry-id-54Centrosome misorientation reduces stem cell division during ageinggilbert.schoenfelder@scienceandtechnology.deHome2008-12-05T00:54:45+01:00http://www.scienceandtechnology.de/page18/page6/files/52d2cec60bbb05c4e4e98f1e99051785-53.html#unique-entry-id-53http://www.scienceandtechnology.de/page18/page6/files/52d2cec60bbb05c4e4e98f1e99051785-53.html#unique-entry-id-53Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopygilbert.schoenfelder@scienceandtechnology.deDevelopment2008-11-15T15:34:53+01:00http://www.scienceandtechnology.de/page18/page6/files/4e11b76985d541caef7111b5d9f34db3-52.html#unique-entry-id-52http://www.scienceandtechnology.de/page18/page6/files/4e11b76985d541caef7111b5d9f34db3-52.html#unique-entry-id-52Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancergilbert.schoenfelder@scienceandtechnology.deCancer2008-11-15T15:30:43+01:00http://www.scienceandtechnology.de/page18/page6/files/f8ee334ce410b278de6d34e62fab2d62-51.html#unique-entry-id-51http://www.scienceandtechnology.de/page18/page6/files/f8ee334ce410b278de6d34e62fab2d62-51.html#unique-entry-id-51Reprogramming Primordial Germ Cells into Pluripotent Stem Cellsgilbert.schoenfelder@scienceandtechnology.deprimordial germ cells2008-10-29T21:55:31+01:00http://www.scienceandtechnology.de/page18/page6/files/4a86058a091b5b874d7cf2001bf5ade8-49.html#unique-entry-id-49http://www.scienceandtechnology.de/page18/page6/files/4a86058a091b5b874d7cf2001bf5ade8-49.html#unique-entry-id-49AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathwaygilbert.schoenfelder@scienceandtechnology.deOhne2008-10-24T02:05:14+02:00http://www.scienceandtechnology.de/page18/page6/files/9c4cb6b3523f5811b7c0dee3d23bbc0c-45.html#unique-entry-id-45http://www.scienceandtechnology.de/page18/page6/files/9c4cb6b3523f5811b7c0dee3d23bbc0c-45.html#unique-entry-id-45Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Aktgilbert.schoenfelder@scienceandtechnology.deHome2008-10-24T01:59:35+02:00http://www.scienceandtechnology.de/page18/page6/files/cdcafe2de6839b526d99932714682905-44.html#unique-entry-id-44http://www.scienceandtechnology.de/page18/page6/files/cdcafe2de6839b526d99932714682905-44.html#unique-entry-id-44Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangiomagilbert.schoenfelder@scienceandtechnology.devegfNFAThemangiomaFlt-1Endothelial cells2008-10-21T23:45:30+02:00http://www.scienceandtechnology.de/page18/page6/files/a50b2239eec61c10b4f2d4c181af47f7-43.html#unique-entry-id-43http://www.scienceandtechnology.de/page18/page6/files/a50b2239eec61c10b4f2d4c181af47f7-43.html#unique-entry-id-43Generation of pluripotent stem cells from adult human testisgilbert.schoenfelder@scienceandtechnology.deprimordial germ cellshumanTestisEmbryonic stem cells2008-10-09T02:28:20+02:00http://www.scienceandtechnology.de/page18/page6/files/39640e965d64f3b5348bc5646edcff3b-42.html#unique-entry-id-42http://www.scienceandtechnology.de/page18/page6/files/39640e965d64f3b5348bc5646edcff3b-42.html#unique-entry-id-42Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanismgilbert.schoenfelder@scienceandtechnology.deDNMT1UHRF1CpGMethylation2008-10-09T02:24:34+02:00http://www.scienceandtechnology.de/page18/page6/files/3115365c93d5acccf77d8b3b4523bbbb-41.html#unique-entry-id-41http://www.scienceandtechnology.de/page18/page6/files/3115365c93d5acccf77d8b3b4523bbbb-41.html#unique-entry-id-41Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1gilbert.schoenfelder@scienceandtechnology.deMethylationDNMT1UHRF1CpG2008-10-09T02:21:58+02:00http://www.scienceandtechnology.de/page18/page6/files/6b93344108d512c5b21caa14c017bf96-40.html#unique-entry-id-40http://www.scienceandtechnology.de/page18/page6/files/6b93344108d512c5b21caa14c017bf96-40.html#unique-entry-id-40Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiationgilbert.schoenfelder@scienceandtechnology.deEpigeneticsEmbryonic stem cellsTranscription2008-10-07T20:03:07+02:00http://www.scienceandtechnology.de/page18/page6/files/2d03e94b52d05b5ca90f6f63f37040a7-39.html#unique-entry-id-39http://www.scienceandtechnology.de/page18/page6/files/2d03e94b52d05b5ca90f6f63f37040a7-39.html#unique-entry-id-39Blocking Them All: β-Arrestins Inhibit Cellular Signalinggilbert.schoenfelder@scienceandtechnology.deG protein-coupled receptorsβ-arrestinsSTAT12008-10-01T00:45:16+02:00http://www.scienceandtechnology.de/page18/page6/files/81209908ed0ca0266ea6641d2a95d4cb-38.html#unique-entry-id-38http://www.scienceandtechnology.de/page18/page6/files/81209908ed0ca0266ea6641d2a95d4cb-38.html#unique-entry-id-38A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Micegilbert.schoenfelder@scienceandtechnology.deTransposonMethylationMiWI2MiLIpiRNA2008-09-26T00:56:55+02:00http://www.scienceandtechnology.de/page18/page6/files/978c1b3c293400e909c30a200405c437-37.html#unique-entry-id-37http://www.scienceandtechnology.de/page18/page6/files/978c1b3c293400e909c30a200405c437-37.html#unique-entry-id-37Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adultsgilbert.schoenfelder@scienceandtechnology.deBisphenol AhumanDiabetesCardiovascular2008-09-16T16:00:00+02:00http://www.scienceandtechnology.de/page18/page6/files/c1713950a88aea8e82ef7b5b00a63ee4-36.html#unique-entry-id-36http://www.scienceandtechnology.de/page18/page6/files/c1713950a88aea8e82ef7b5b00a63ee4-36.html#unique-entry-id-36The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signalinggilbert.schoenfelder@scienceandtechnology.deFrizzledWntCateninvan GoghEpithelium2008-09-15T21:12:45+02:00http://www.scienceandtechnology.de/page18/page6/files/0ed04dabb021288000619d99acb71a12-35.html#unique-entry-id-35http://www.scienceandtechnology.de/page18/page6/files/0ed04dabb021288000619d99acb71a12-35.html#unique-entry-id-35Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integritygilbert.schoenfelder@scienceandtechnology.devegfAngiogenesisEndotheliumFGF2008-09-15T21:10:06+02:00http://www.scienceandtechnology.de/page18/page6/files/838c6f763d6fc5a6c8a0eecf09b9d045-34.html#unique-entry-id-34http://www.scienceandtechnology.de/page18/page6/files/838c6f763d6fc5a6c8a0eecf09b9d045-34.html#unique-entry-id-34Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis.gilbert.schoenfelder@scienceandtechnology.deBisphenol ApancreasMouseInsulinglucose2007-10-30T21:00:30+01:00http://www.scienceandtechnology.de/page18/page6/files/5e73ef51dc75ab135ba8ae6b4d78c981-33.html#unique-entry-id-33http://www.scienceandtechnology.de/page18/page6/files/5e73ef51dc75ab135ba8ae6b4d78c981-33.html#unique-entry-id-33Bisphenol A and Risk of Metabolic Disordersgilbert.schoenfelder@scienceandtechnology.deBisphenol AhumanDiabeteshealth effect2008-09-16T16:00:00+02:00http://www.scienceandtechnology.de/page18/page6/files/0b942031a0db21a518464cf7dbbafdd7-32.html#unique-entry-id-32http://www.scienceandtechnology.de/page18/page6/files/0b942031a0db21a518464cf7dbbafdd7-32.html#unique-entry-id-32Pancreatic Insulin Content Regulation by the Estrogen Receptor ERαgilbert.schoenfelder@scienceandtechnology.deBisphenol AEstrogenEstrogen receptorsErkMouse2008-09-15T20:54:18+02:00http://www.scienceandtechnology.de/page18/page6/files/8856ebd83cb2ff0a5358106d324e7d89-31.html#unique-entry-id-31http://www.scienceandtechnology.de/page18/page6/files/8856ebd83cb2ff0a5358106d324e7d89-31.html#unique-entry-id-31Bisphenol A at Environmentally Relevant Doses Inhibits Adiponectin Release from Human Adipose Tissue Explants and Adipocytesgilbert.schoenfelder@scienceandtechnology.deBisphenol AAdiponectinhumanAdipocytes2008-09-15T20:47:48+02:00http://www.scienceandtechnology.de/page18/page6/files/554925477ab35fe65c835884d74fbaf1-30.html#unique-entry-id-30http://www.scienceandtechnology.de/page18/page6/files/554925477ab35fe65c835884d74fbaf1-30.html#unique-entry-id-30Natural selection of FLT1 alleles and their association with malaria resistance in uterogilbert.schoenfelder@scienceandtechnology.deFlt-1Malariapregnancyvegfgenotype2008-09-09T18:22:49+02:00http://www.scienceandtechnology.de/page18/page6/files/557823bd6b1f3cde496d679b94f4bf6f-29.html#unique-entry-id-29http://www.scienceandtechnology.de/page18/page6/files/557823bd6b1f3cde496d679b94f4bf6f-29.html#unique-entry-id-29Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: The Generation R study.gilbert.schoenfelder@scienceandtechnology.deBisphenol AhumanExposureurine2008-09-09T18:08:27+02:00http://www.scienceandtechnology.de/page18/page6/files/96b6013d0109f1140a1844972f7d0904-28.html#unique-entry-id-28http://www.scienceandtechnology.de/page18/page6/files/96b6013d0109f1140a1844972f7d0904-28.html#unique-entry-id-28Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates.gilbert.schoenfelder@scienceandtechnology.deBisphenol AprimatesBrain2008-09-09T17:44:56+02:00http://www.scienceandtechnology.de/page18/page6/files/5963c7435ac38dd3b3eac637d657af12-27.html#unique-entry-id-27http://www.scienceandtechnology.de/page18/page6/files/5963c7435ac38dd3b3eac637d657af12-27.html#unique-entry-id-27Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini gilbert.schoenfelder@scienceandtechnology.deCaspaseprogrammed cell deathApoptosis2008-09-08T23:25:52+02:00http://www.scienceandtechnology.de/page18/page6/files/d0d7932d7dd1314ab5587b5cf62bc04b-26.html#unique-entry-id-26http://www.scienceandtechnology.de/page18/page6/files/d0d7932d7dd1314ab5587b5cf62bc04b-26.html#unique-entry-id-26UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnovergilbert.schoenfelder@scienceandtechnology.deHIF1αp97ubiquitin ligases2008-09-08T23:19:36+02:00http://www.scienceandtechnology.de/page18/page6/files/2d89571bfb32f543c6c2235ba0e83d47-25.html#unique-entry-id-25http://www.scienceandtechnology.de/page18/page6/files/2d89571bfb32f543c6c2235ba0e83d47-25.html#unique-entry-id-25Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activationgilbert.schoenfelder@scienceandtechnology.desh2sh2-kinaseTyrosine Kinase2008-09-08T23:15:13+02:00http://www.scienceandtechnology.de/page18/page6/files/3f43a035d26c7cc7be4c9f4e1cc1ca41-24.html#unique-entry-id-24http://www.scienceandtechnology.de/page18/page6/files/3f43a035d26c7cc7be4c9f4e1cc1ca41-24.html#unique-entry-id-24Human-Specific Gain of Function in a Developmental Enhancergilbert.schoenfelder@scienceandtechnology.deEnhancerDevelopmenthuman2008-09-08T23:06:06+02:00http://www.scienceandtechnology.de/page18/page6/files/ce43f2a07b461fe9bad95f53b40250ae-23.html#unique-entry-id-23http://www.scienceandtechnology.de/page18/page6/files/ce43f2a07b461fe9bad95f53b40250ae-23.html#unique-entry-id-23Shadow Enhancers as a Source of Evolutionary Noveltygilbert.schoenfelder@scienceandtechnology.deChIP-chip assaysevolutionshadow enhancer2008-09-08T22:59:29+02:00http://www.scienceandtechnology.de/page18/page6/files/cf2e68d93eff204d8c3b5d7a265d4bf2-22.html#unique-entry-id-22http://www.scienceandtechnology.de/page18/page6/files/cf2e68d93eff204d8c3b5d7a265d4bf2-22.html#unique-entry-id-22Calcification of Multipotent Prostate Tumor Endotheliumgilbert.schoenfelder@scienceandtechnology.deEndothelial progenitor cellProstateCalcificationEndothelium2008-09-08T22:50:53+02:00http://www.scienceandtechnology.de/page18/page6/files/98788c598151e8d89ccb220eafd5fec3-21.html#unique-entry-id-21http://www.scienceandtechnology.de/page18/page6/files/98788c598151e8d89ccb220eafd5fec3-21.html#unique-entry-id-21Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agentsgilbert.schoenfelder@scienceandtechnology.deEndothelial progenitor cellCellcycleMouse2008-09-08T22:42:32+02:00http://www.scienceandtechnology.de/page18/page6/files/6438e40aab67d8c1403e89db4d8d13f2-20.html#unique-entry-id-20http://www.scienceandtechnology.de/page18/page6/files/6438e40aab67d8c1403e89db4d8d13f2-20.html#unique-entry-id-20Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytesgilbert.schoenfelder@scienceandtechnology.deCardiomyocyteg protein signallinghistone deacetylase kinaseheart failure2008-09-02T15:08:14+02:00http://www.scienceandtechnology.de/page18/page6/files/d0b8bf8ee8151fe041728dac401e7462-19.html#unique-entry-id-19http://www.scienceandtechnology.de/page18/page6/files/d0b8bf8ee8151fe041728dac401e7462-19.html#unique-entry-id-19The H19 locus acts in vivo as a tumor suppressor gilbert.schoenfelder@scienceandtechnology.deCancerTumor suppressorgenomic imprintingMurine models2008-09-02T15:03:38+02:00http://www.scienceandtechnology.de/page18/page6/files/0354cd0267785a78cfc8d3072f9adb12-18.html#unique-entry-id-18http://www.scienceandtechnology.de/page18/page6/files/0354cd0267785a78cfc8d3072f9adb12-18.html#unique-entry-id-18High-resolution magnetic resonance histology of the embryonic and neonatal mouse: A 4D atlas and morphologic databasegilbert.schoenfelder@scienceandtechnology.deMouseDigital atlasDevelopment2008-09-02T14:52:34+02:00http://www.scienceandtechnology.de/page18/page6/files/6ad606a9a978655b044ff855c00950cb-17.html#unique-entry-id-17http://www.scienceandtechnology.de/page18/page6/files/6ad606a9a978655b044ff855c00950cb-17.html#unique-entry-id-17200 anatomical structures have been identified and labeled. Also, matching optical histology and analysis tools are provided to compare multiple specimens at multiple developmental stages. The utility of the approach is demonstrated in characterizing cardiac septal defects in conditional mutant embryos lacking the Smoothened receptor gene. Finally, a collaborative paradigm is presented that allows sharing of data across the scientific community. This work makes magnetic resonance microscopy of the mouse embryo and neonate broadly available with carefully annotated normative data and an extensive environment for collaborations. PNAS 2008 105:12331-12336; published ahead of print August 19, 2008, doi:10.1073/pnas.0805747105]]>Information flow and optimization in transcriptional regulationgilbert.schoenfelder@scienceandtechnology.deTranscription2008-09-02T14:50:06+02:00http://www.scienceandtechnology.de/page18/page6/files/ab6dc179283c11f7bcfe38c2d9f9213a-16.html#unique-entry-id-16http://www.scienceandtechnology.de/page18/page6/files/ab6dc179283c11f7bcfe38c2d9f9213a-16.html#unique-entry-id-16Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomasgilbert.schoenfelder@scienceandtechnology.deAngiogenesisvasculogenesisvegfEndothelial progenitor cellCancer2008-09-02T14:43:45+02:00http://www.scienceandtechnology.de/page18/page6/files/31991b72a00f6301ba66fbeb3b81b120-15.html#unique-entry-id-15http://www.scienceandtechnology.de/page18/page6/files/31991b72a00f6301ba66fbeb3b81b120-15.html#unique-entry-id-1550 reports (2, 3), neglecting to quote key articles or utilize relevant models, and have drawn unsubstantiated conclusions about the contribution of endothelial progenitor cells (EPCs) to tumor angiogenesis that are not supported by their nonquantitative data and superficially executed experiments. Their study (1) is flawed in experimental design and data interpretation. For example, they do not cite their own publication demonstrating the existence of VEGFR2+ EPCs (4) and neglect mentioning clinical validation (5, 6) and acknowledging mouse genetic models (2, 3), which provide convincing evidence for functional incorporation of EPCs into neovessels. Every figure lacks stereoconfocal-microscopic quantification of vessels that are presented as poorly defined longitudinal–linear streaks. Plasma VEGF-A levels were not measured in vivo in mice treated with VEGF-A, questioning their low level of VEGFR2+ EPC detection (3). Indeed, their FACS analysis is inaccurate because of (i) unconvincing CD31/VE-cadherin/VEGFR2 expression detected on MS-1 endothelium used as positive control and (ii) failure to show long-term marrow engraftment of donor-derived hematopoietic and authentic VEGFR2+LacZ+ colony-forming EPCs. APCmin mice develop only obstructive adenomas, rather than adenocarcinomas; therefore, it is an inappropriate model to study EPC incorporation, as Spring et al. (7) (not quoted) demonstrate that EPCs do not contribute to adenomas but contribute only to carcinomas/metastatic tumors. In the parabiotic model, wild-type EPCs compete with GPF+ EPCs, which underestimates EPC recruitment. Finally, study of 6-month-old VEGF-A-loaded Matrigel plugs in mice is impossible because Matrigel plugs are degraded within 2 months, particularly when VEGF-A by itself does not induce neoangiogenesis. No quantification of patent vessels in Matrigel plugs was provided. This article fails to disprove the established role of EPCs in supporting neoangiogenesis in certain tumors (3, 5) and metastatic transition (2) PNAS 2008 105:E54; published ahead of print August 20, 2008, doi:10.1073/pnas.0804876105]]>Epigenetic Reprogramming by Adenovirus e1agilbert.schoenfelder@scienceandtechnology.deEpigeneticsTranscriptionAdenovirus2008-08-22T09:53:45+02:00http://www.scienceandtechnology.de/page18/page6/files/56004b17774178d6e19e6d998a9bf4fa-14.html#unique-entry-id-14http://www.scienceandtechnology.de/page18/page6/files/56004b17774178d6e19e6d998a9bf4fa-14.html#unique-entry-id-14Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early developmentgilbert.schoenfelder@scienceandtechnology.deMethylationBisphenol AEpigenetics2007-08-07T09:18:01+02:00http://www.scienceandtechnology.de/page18/page6/files/91a47fdff4f0f70f68912e281e00b67b-13.html#unique-entry-id-13http://www.scienceandtechnology.de/page18/page6/files/91a47fdff4f0f70f68912e281e00b67b-13.html#unique-entry-id-13An Sp1/Sp3 Binding Polymorphism Confers Methylation Protectiongilbert.schoenfelder@scienceandtechnology.deEpigeneticsMethylationChromatinSp1Sp3Cancer2008-08-28T01:21:14+02:00http://www.scienceandtechnology.de/page18/page6/files/2ca05895944e0b283c59acada8971d5e-12.html#unique-entry-id-12http://www.scienceandtechnology.de/page18/page6/files/2ca05895944e0b283c59acada8971d5e-12.html#unique-entry-id-12S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neuronsgilbert.schoenfelder@scienceandtechnology.deEpigeneticsChromatinhistone deacetylase2008-08-28T01:05:05+02:00http://www.scienceandtechnology.de/page18/page6/files/38149a4318391e37878be5549e7d03cb-11.html#unique-entry-id-11http://www.scienceandtechnology.de/page18/page6/files/38149a4318391e37878be5549e7d03cb-11.html#unique-entry-id-11Mouse development with a single E2F activatorgilbert.schoenfelder@scienceandtechnology.deDevelopment2008-08-28T00:57:01+02:00http://www.scienceandtechnology.de/page18/page6/files/2d719ef50dbc1dd37970cde2b0594992-10.html#unique-entry-id-10http://www.scienceandtechnology.de/page18/page6/files/2d719ef50dbc1dd37970cde2b0594992-10.html#unique-entry-id-10Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testisgilbert.schoenfelder@scienceandtechnology.deSTEMCELLS CadherinTestis2008-08-28T00:51:36+02:00http://www.scienceandtechnology.de/page18/page6/files/ffb17d388bc46a47f3a9651136c9d04b-9.html#unique-entry-id-9http://www.scienceandtechnology.de/page18/page6/files/ffb17d388bc46a47f3a9651136c9d04b-9.html#unique-entry-id-9Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development gilbert.schoenfelder@scienceandtechnology.deSTEMCELLSTranscription2008-08-27T01:14:45+02:00http://www.scienceandtechnology.de/page18/page6/files/62a67a170a55f702b92821c76ff6f41d-7.html#unique-entry-id-7http://www.scienceandtechnology.de/page18/page6/files/62a67a170a55f702b92821c76ff6f41d-7.html#unique-entry-id-7A Novel Molecular Solution for Ultraviolet Light Detection in Caenorhabditis elegansgilbert.schoenfelder@scienceandtechnology.deUltraviolet Light2008-08-27T01:00:26+02:00http://www.scienceandtechnology.de/page18/page6/files/297a592f2a791be48952b840dedb0b48-6.html#unique-entry-id-6http://www.scienceandtechnology.de/page18/page6/files/297a592f2a791be48952b840dedb0b48-6.html#unique-entry-id-6Pancreatic Insulin Content Regulation by the Estrogen Receptor ERαgilbert.schoenfelder@scienceandtechnology.deBisphenol A2008-04-30T02:32:45+02:00http://www.scienceandtechnology.de/page18/page6/files/f1df5a1291bf45a5ec220f2eb587e447-5.html#unique-entry-id-5http://www.scienceandtechnology.de/page18/page6/files/f1df5a1291bf45a5ec220f2eb587e447-5.html#unique-entry-id-5Widespread changes in protein synthesis induced by microRNAsgilbert.schoenfelder@scienceandtechnology.deMicroRNAs2008-08-25T02:07:57+02:00http://www.scienceandtechnology.de/page18/page6/files/39bf007884a054e83c00b8cbbc0215c1-4.html#unique-entry-id-4http://www.scienceandtechnology.de/page18/page6/files/39bf007884a054e83c00b8cbbc0215c1-4.html#unique-entry-id-4The impact of microRNAs on protein outputgilbert.schoenfelder@scienceandtechnology.deMicroRNAs2008-08-25T02:05:20+02:00http://www.scienceandtechnology.de/page18/page6/files/b61d50070caa919f932328ebd965712e-3.html#unique-entry-id-3http://www.scienceandtechnology.de/page18/page6/files/b61d50070caa919f932328ebd965712e-3.html#unique-entry-id-3Essential roles of PI(3)K–p110beta in cell growth, metabolism and tumorigenesisgilbert.schoenfelder@scienceandtechnology.deCancer2008-08-07T01:59:23+02:00http://www.scienceandtechnology.de/page18/page6/files/32b6159f8d4cbaf07be55365c2426006-2.html#unique-entry-id-2http://www.scienceandtechnology.de/page18/page6/files/32b6159f8d4cbaf07be55365c2426006-2.html#unique-entry-id-2Genome-scale DNA methylation maps of pluripotent and differentiated cellsgilbert.schoenfelder@scienceandtechnology.deEpigeneticsDevelopmentMethylationDNA2008-08-07T01:55:40+02:00http://www.scienceandtechnology.de/page18/page6/files/38c777d2a44fab0e83c6c47a0977c098-1.html#unique-entry-id-1http://www.scienceandtechnology.de/page18/page6/files/38c777d2a44fab0e83c6c47a0977c098-1.html#unique-entry-id-1