Cellcycle
Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents
08/09/2008
Several
hypotheses have been proposed to explain how
antiangiogenic drugs enhance the treatment efficacy
of cytotoxic chemotherapy, including impairing the
ability of chemotherapy-responsive tumors to regrow
after therapy. With respect to the latter, we show
that certain chemotherapy drugs, e.g., paclitaxel,
can rapidly induce proangiogenic bone marrow-derived
circulating endothelial progenitor (CEP) mobilization
and subsequent tumor homing, whereas others, e.g.,
gemcitabine, do not. Acute CEP mobilization was
mediated, at least in part, by systemic induction of
SDF-1α and could be prevented by various procedures
such as treatment with anti-VEGFR2 blocking
antibodies or paclitaxel treatment in CEP-deficient
Id mutant mice, both of which resulted in enhanced
antitumor effects mediated by paclitaxel, but not by
gemcitabine.
Cancer Cell, Volume 14, Issue 3, 9 September 2008, Pages 263-273
Cancer Cell, Volume 14, Issue 3, 9 September 2008, Pages 263-273
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