glucose
Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis.
30/10/2007
The link between endocrine disruptors and altered
blood glucose homeostasis has been recently
suggested. Epidemiological studies have correlated
levels of phthalates, dioxins and persistent organic
pollutants with alterations of blood glucose
homeostasis in humans. Environmentally relevant doses
of the ubiquitous endocrine disruptor bisphenol-A
(BPA) have profound effects on mice endocrine
pancreas--an essential tissue involved in glucose
metabolism. BPA exerts rapid non-genomic effects on
insulin releasing beta-cells and glucagon releasing
alpha-cells within freshly isolated islets of
Langerhans. In vivo, a single BPA injection of 10
microg/kg rapidly increases plasma insulin and
concomitantly decreases glycaemia. When mice were
treated with BPA 100 microg/kg/day for 4 days, the
environmental oestrogen produced an increase in
beta-cell insulin content along with a post-prandial
hyperinsulinaemia and insulin resistance. The results
reviewed here demonstrate that doses well below the
current lowest observed adverse effect level
considered by the US-EPA, disrupt pancreatic
beta-cell function producing insulin resistance in
male mice. Therefore, this altered blood glucose
homeostasis by BPA exposure may enhance the risk of
developing type II diabetes.
International Journal of Andrology, Volume 31 Issue 2, Pages 194 - 200, 2007
International Journal of Andrology, Volume 31 Issue 2, Pages 194 - 200, 2007
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