Laboratory of Molecular Toxicology

Recent Publications

ARTICLES
 
1. E. Dippel, B. Mayer, G. Schönfelder, B.M. Czarnetzki and R. Paus
Distribution of Constitutive Nitric Oxide Synthase Immunoreactivity and NADPH-Diaphorase Activity in Murine Telogen arid Anagen Skin
Joumal of Investigative Dermatology, Vol. 103, No. 1, July 1994, 112-115

2. R. Graf, G. Schönfelder, J.-U. Langer, T. Öney, W. Reutter, H.H.H.W. Schmidt
Das extravasale kontraktile System der Humanplazenta: Ein neuer Aspekt für die Funktion des Organs ?
Zentralblatt für Gynäkologie 116 (1994), 344-346

 3. R. Graf, J.-U. Langer, G. Schönfelder, T. Öney, S. Hartel-Schenk, W. Reutter and H.H.H.W. Schmidt
The Extravascular Contractile System In The Human Placenta, Morphological And Immunocytochemical Investigations
Anatomy and Embryology (1994) 190: 541-548
 
4. R. Graf, G. Schönfelder, M. Mühlberger and M. Gutsmann
The Perivascular Contractile Sheath of Human Placental Stem Villi: Its Isolation and Characterization
Placenta  (1995), 16, 57-66

 5. L. Liefeldt,W. Böcker, G. Schönfelder,M. Zintz and M. Paul
Regulation of endothelin receptor mRNA in transgenic rats expressing the human endothelin-II gene
Journal of Cardiovascular Pharmacology (1995) 26 (Suppl. 3): S32-S33

 6. G. Schönfelder, M. John, H. Hopp, N. Fuhr, M. van der Giet and Martin Paul
Expression of inducible nitric oxide synthase in placenta of women with gestational diabetes
The FASEB Journal, (1996) Volume 10, Issue 7, 777-784
    
7. R. Köhler, G. Schönfelder, H. Hopp, A. Distler and J. Hoyer
Stretch-Activated Cation Channels In Human Umbilical Vein Endothelium
Journal of Hypertension (1998),16: 1149-1156

 8.  Harren M, Schonfelder G, Paul M, Horak I, Riecken EO, Wiedenmann B and John M
High expression of inducible nitric oxide synthase correlates with intestinal inflammation of
interleukin-2-deficient mice.
Ann N Y Acad Sci (1998) Nov 17; 859:210-5

 9. Sporbert, K. Mertsch, A. Smolenski, R. F. Haseloff, G. Schönfelder, M. Paul, P. Ruth, U. Walter and I.E. Blasig
Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes
Molecular Brain Research 67 (1999): 258-266

10. D. Freyer, R. Manz, A. Ziegenhorn, M. Weih, K. Angstwurm, W.-D. Döcke, A. Meisel, R.R. Schumann, G. Schönfelder, U. Dirnagel, and J.R. Weber
Cerebral Endothelial Cells Release TNF-a After Stimulation With Cell Walls Of Streptococcus Pneumoniae And Regulate Inducible Nitric Oxide Synthase And ICAM-1 Expression Via Autocrine Loops
The Journal of Immunology (1999), 163: 4308-4314
 
11. L. Liefeldt, G. Schönfelder, W. Böcker, B. Hocher, C.E.Talsness, R. Rettig and M. Paul
Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo 
Journal of Molecular Medicine (1999) Jul; 77(7): 565-574

12. I.E. Blasig, H. Giese, M.L. Schroeter, A. Sporbert, D.I. Utepbergenov, I.B. Buchwalow, K. Neubert,
G. Schönfelder, D. Freyer, I. Schimke, W.-E. Siems, M. Paul, R.F. Haseloff and R. Blasig
NO and oxy-radical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier
Microvascular Research (2001) Sep; 62(2): 114-27

13. G. Schönfelder, B. Flick, L. Mayr, C. Talsness, M. Paul and I. Chahoud
In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina
Neoplasia (2002) Mar-Apr; 4(2):98-102.

14. M. Ketteler, R. Westenfeld, A. Gawlik, S. Bachmann, A. Frey, G. Schönfelder, M. Paul, A. Distler and E. de Heer
Nitric oxide synthase isoform expression in acute versus chronic anti-thy1 Nephritis
Kidney Int. (2002) Mar; 61(3): 826-33

15. G. Schönfelder , W. Wittfoht , H. Hopp, C.E. Talsness , M. Paul and I. Chahoud
Parent bisphenol A accumulation in the human maternal-fetal-placental unit
Environmental Health Perspectives (2002), 110:A703-A707
 
16. R. Wolf, G. Schönfelder, M. Paul and U. Blume-Peytavi
Nitric oxide in the human hair follicle: Constitutive and dihydrotestosterone induced nitric oxide synthase expression and NO production in dermal papilla cells
Journal of Molecular Medicine (2003) Feb; 81(2): 110-7

17.  G. Schönfelder, N. Fuhr, D. Hadzidiakos, M. John, H. Hopp and M. Paul
Preeclampsia is associated with loss of neuronal nitric oxide synthase expression in vascular smooth muscle cells of the human umbilical cord
Histopathology (2004) Feb; 44(2): 116-28

18. G. Schönfelder, K. Friedrich, M. Paul and I. Chahoud
Developmental effects of prenatal exposure to bisphenol A on the uterus of rat offspring
Neoplasia (2004) Sep; 6(5): 584-594

19. V. Jankowski, M. Tölle, R. Vanhoulder, G. Schönfelder, M. van der Giet, L. Henning, M. Paul, H. Schlüter, W. Zidek and J. Jankowski
Identification of uridine adenosine tetraphosphate (Up4A) as an endothelial-derived vasoconstrictive factor.
Nature Medicine (2005) Feb; 11(2): 223-7

20. M.  Tolle, B. Levkau, P.  Keul, V. Brinkmann, G.  Giebing, G. Schonfelder, M. Schafers,
K. von Wnuck Lipinski, J. Jankowski, V. Jankowski, J. Chun, W. Zidek and M. van der Giet
Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P3
Circulation Research 2005 Apr 29; 96(8):913-20

21.  V. Jankowski, R. Vanholder, M. van der Giet, L. Henning, M. Tölle, G. Schönfelder, A. Krakow, S. Karadogan, N. Gustavsson, J. Gobom, J. Webb, H. Lehrach, G. Giebing, H. Schlüter, K.F. Hilgers, W. Zidek, J. Jankowski
Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by MALDI-TOF-TOF-mass spectrometric analysis
Hypertension 2005 Sep; 46(3):591-7

22. Gilbert Schönfelder
The biological impact of estrogens on gender differences in congestive heart failure
Cardiovasc Res. 2005 Sep 1;67(4):573-4

23. Oliver Krysiak, Anja Bretschneider, Enhong Zhong, Jessie Webb, Hartmut Hopp, Stefan Verloren, Norbert Fuhr, Malgorzata Lanowska, Andreas Nonnenmacher, Roland Vetter, Joachim Jankowski, Martin Paul and Gilbert Schönfelder
Soluble vascular endothelial growth factor receptor-1 (sflt-1) mediates downregulation of flt-1 and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF
Circulation Research 2005; 97, 1253-1261
  
24. D. Menendez, O. Krysiak, A. Inga, B. Gehrandt, M.A. Resnick and G. Schönfelder
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network
The Proceedings of the National Academy of Sciences USA (PNAS), 1406–1411, January 31, 2006, vol. 103, no. 5

25.  H.R. Kohler, W. Kloas, M. Schirling, I. Lutz, A.L. Reye, J.S. Langen, R. Triebskorn, R. Nagel and
G. Schönfelder
Sex steroid receptor evolution and signalling in aquatic invertebrates
Ecotoxicology. 2007 Feb; 16(1):131-43

26.  D. Menendez, A. Inga, J. Snipe, O. Krysiak, G. Schönfelder and M.A. Resnick
A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1
Mol Cell Biol. 2007 Apr; 27(7):2590-600

27. C.R. Ehrenstein, J. Rentzsch, S. Runkel, A. Schneider and G. Schönfelder
Endothelial progenitor cells in breast cancer patients
Breast Cancer Res Treat (2007) 106:343–349

28. John Peterson Myers, Frederick S. Vom Saal, Benson T. Akingbemi, Koji Arizono, Scott Belcher, Theo Colborn, Ibrahim Chahoud, D. Andrew Crain, Francesca Farabollini, Louis J. Guillette, Jr., Terry Hassold, Shuk-Mei Ho, Patricia A. Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Hans Laufer, Michele Marcus, John A. Mclachlan, Angel Nadal, Jörg Oehlmann, Nicolás Olea, Paola Palanza, Stefano Parmigiani, Beverly S. Rubin, Gilbert Schoenfelder, Carlos Sonnenschein, Ana M. Soto, Chris E. Talsness, Julia A. Taylor, Laura N. Vandenberg, John G. Vandenbergh, Sarah Vogel, Cheryl S. Watson, Wade V. Welshons, R. Thomas Zoeller
Why public health agencies cannot depend upon ‘good laboratory practices’ as a criterion for selecting data: the case of bisphenol A
Environ Health Perspect 117:309–315 (2009) . doi:10.1289/ehp.0800173

 
REVIEWS
 
1. M. Paul, P. Stock, M. Langheinrich, L. Liefeldt, G. Schönfelder and M. Böhm
Role Of The Cardiac Renin Angiotensin System In Human Heart Failure
Adv Exp Med Biol. (1995); 377: 279-83

2. Gilbert Schönfelder
Epigenetik: Wie die Umwelt unsern Blutdruck beeinflussen kann
Diabetes, Stoffwechsel und Herz, Band 18, 3/2009, 3-4

 
 
BOOKCHAPTER AND PROCEEDINGS
 
1. L.  Liefeldt, G. Schönfelder, P. Stock, W. Böcker, H. Bohnemeier, M. Langheinrich,
H.D. Orzechowski, M. van der Giet, D. Ganten and M. Paul
Transgene Tiermodelle in der Klinischen Pharmakologie am Beispiel der Hypertonieforschung
Klinische Pharmakologie aktuell (1995) 6(2), 84-88
 
2. A.J. Kroesen, M. John, K.Möller, G.Schönfelder, B. Wiedemann and H.J. Buhr
Expression of inducible Nitric Oxide-Synthase (iNOS) in Inflammatory bowel disease (IBD)
Langenbecks Arch Chir Suppl I (Forumband 1996), 323-326
 
3. A.J. Kroesen, M. John, G.Schönfelder, N. Runkel, B. Wiedemann and H.J.Buhr
Expression of inducible nitric-oxide synthase in pouchitis after ileoanal-pouch- anastomosis due to ulcerative colitis
Langenbecks Arch Chir Suppl I (Forumband 1997), 451-454
 
4. Fuhr N.; Schönfelder G.; John M.; Hopp H.; Paul M.; Weitzel H.
Expression of different NOS isoforms in human placenta and umbilical cord.
Labor and Delivery (1998), The Parthenon Publishing Group, edited by. E.V. Cosmi
and G. Montanino, 319-321
 
5. Grimm D, Schönfelder G, Paul M.
Apoptosis in cardiac myocytes. Effects of Angiotensin II.
in Apoptosis in Cardiac Biology edited by Schunkert H, Riegger GAJ. Kluwer Academic Publishers, Boston-Dordrecht-London 1999; 317-327.
 
6. Gilbert Schönfelder
Plazenta-Biochemie
Schwangerschaftshochdruck (2001), Hrsg.: Heilmann / Rath, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 182-199
 
7. G. Schönfelder , D. Schwarz , T. Gerloff , M. Paul  and I. Roots
Genetic variability: Implications for toxicogenomic research
Textbook: Handbook of Toxicogenomics-Strategies and Applications (2005); Borlak, Jürgen (Hrsg.), Wiley-VCH, Weinheim
 
8. Gilbert Schönfelder and Anja Bretschneider
Regulation des VEGF-Rezeptors FLT-1 bei Präeklampsie
Kontroversen in der Geburtsmedizin; Herausgeber Hartmut Hopp, 1. Auflage 2008, Akademos, Hamburg